Once the students have become familiar with chromosomes and karyotypes they will need to test their knowledge. The Biology Project has a great site for such an evaluation.

The Karyotyping Activity allows students to evaluate patient case histories complete their karytopes and diagnose any missing or extra chromosomes. There are two questions for each patient and an Internet search component to complete.

For the Internet search you may want to select specific sites for your students to visit rather then having them conduct a search on a multi search engine such as dogpile.

1. What notation would you use to characterize Patient A's karyotype ?
2. What diagnosis would you give Patient A?
3. What notation would you use to characterize Patient B's karyotype ?
4. What diagnosis would you give Patient B?
5. What notation would you use to characterize Patient C's karyotype ?
6. What diagnosis would you give Patient C?

Using the Internet.

Klinefelter's syndrome

1. What is this abnormality?
2. What are the symptoms?
3. List the web address and a brief summary of each site you found for this chromosomal abnormality. (list at least 2)

Down's syndrome

1. What is this abnormality?
2. What are the symptoms?

List the web address and a brief summary of each site you found for this chromosomal abnormality. (list at least 2)

Trisomy 13 syndrome

1. What is this abnormality?
2. What are the symptoms?

List the web address and a brief summary of each site you found for this chromosomal abnormality. (list at least 2)